I would have to say that one calibration at the begining of the season for each header would do. Also calibrate the deck plates, tilt, and concave indicators. And I would agree that if you have troubles, a recalibration could be helpful. The 50 and 60 series combine remembers the calibrations for each type of newer head. Their is a jumper wire in the harness of the head to tell the combine which header is atatched. Different pin combinations give you a corn head, flex head, etc.