We currently run a 4-38 on our M2, we run comfortably about 3.3 mph in 150 bu corn. Next year we will run 6-30, an increase of plant population of about 14% with spacing we are planning on, I hope to run 2.5 mph. We open our bottom sieve to 3_4", otherwise our tailings return gets overloaded, then you are reshelling corn again. Also it is my understanding that there are long and short shoe M2 and M3 combines out there, ours unfortunatly is a short shoe corn soy special. Yield is what we have been disapointed about, I expect to be in the field longer if the crop is better, nice problem to have. Also, if you are 4 row wide and you have a big problem and need someone else to shell your corn, 6-30 is common and easier to get help. But to answer you question, M2 and M3 do pretty well with 6row, They even made 6-30s for F2 and F3, cleaning capacity is the biggest issue. Good luck