I don't bother really. I wear work clothes with coveralls in the winter. They can get stained or ripped and it's all good because the animals and crops won't judge me. Of course, I don't leave my property in those clothes.
Aprons are a lifesaver when it comes to protecting my clothing. When it comes to detergent, I like the Tide with Downy liquid added in. My laundry comes out smelling great after I use that stuff. OxiClean is my go-to for getting out stains.
I'm not positive that it truly helps or not, but I think clothes smell fresher and look better when I throw in some washing soda with the load. I use All Free and Clear for detergent. I have sensitive skin.