A neighbor's 2388 was losing power and they found that the hand priming pump had a bad diaphram and was allowing air to enter the system. Our 2388 started losing power one day while cutting soybeans. I took off the water separator filter and there was a piece clear plastic in the hole, partially blocking off fuel. looked like some of the plastic the filter came wrapped in. I have no idea how it got in there. It had probably 200 hours on that filter and this was the first problem. After I changed the filter, it evidently got some air in it and ran rough. We purged it several times with the hand pump. It finally cleared up. A friend of mine bought a new 1460 way back when. From day one, it would be running fine then suddenly lose power. Dealer replaced filters, then fuel pump, all to no avail. Finally they removed the fuel tank and found a ping-pong ball with a hole punched in it. It had filled with fuel, so it sank, and every so often would get sucked over the hole in the tank. Dealer found out this wasn't an isolated incident. Seems IH was having trouble with the unions at it's plant and someone had sabotaged the combine. So it could be air or an obstruction. Good luck, and hope you find a solution.