If you have a retail store, the weekends are your busiest time. My wife and I used to have an antiques shop. 90% of our business was on the weekends, and we didn't complain about that.
If you're a dairy farmer, there are really no weekends. When I had a dairy goat farm, I had to milk my goats 24/7. At least I didn't work my day job on weekends, so I could do more farm chores and run errands on weekend.